Causal Concepts Guiding Model Specification in Systems Biology
نویسندگان
چکیده
منابع مشابه
Probabilistic Computational Causal Discovery for Systems Biology
Discovering the causal mechanisms of biological systems is necessary to design new drugs and therapies. Computational Causal Discovery (CD) is a field that offers the potential to discover causal relations and causal models under certain conditions with a limited set of interventions / manipulations. This chapter reviews the basic concepts and principles of CD, the nature of the assumptions to ...
متن کاملRestructuring Causal Concepts
Typical studies of concept learning in adults address the learning of novel concepts, but much of learning involves the updating and restructuring of familiar conceptual domains. Research on conceptual change explores this issue directly but differs greatly from the formal approach of the adult learning studies. This paper bridges these two areas to advance our knowledge of the mechanisms under...
متن کاملThe TETRAD Project: Constraint Based Aids to Causal Model Specification.
The statistical community has brought logical rigor and mathematical precision to the problem of using data to make inferences about a model's parameter values. The TETRAD project, and related work in computer science and statistics, aims to apply those standards to the problem of using data and background knowledge to make inferences about a model's specification. We begin by drawing the analo...
متن کاملCausal model selection tests in systems genetics
We develop a novel hypothesis testing framework for causal inference among pairs of phenotypes in the context of segregating populations. Our model selection test extends Vuong’s test to the case of three misspecified models, to handle the full range of possible causal relationships among a pair of traits, namely, causal, reactive or independent models. The ability to properly address misspecif...
متن کاملThe Epistemology of Causal Selection: Insights from Systems Biology
Among the many causes of an event, how do we distinguish the important ones? Are there ways to distinguish among causes on principled grounds that integrate both practical aims and objective knowledge? Psychologist Tania Lombrozo has suggested that causal explanations “identify factors that are ‘exportable’ in the sense that they are likely to subserve future prediction and intervention” (Lombr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Disputatio
سال: 2017
ISSN: 0873-626X
DOI: 10.1515/disp-2017-0016